Jakura 5mg

US$ 0.63

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SKU	2689
Generic Name	Tofacitinib
Manufacturer	Hetero Labs Ltd, India

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60 Tablet/s

US$ 0.62

US$ 37.5025%US$ 50.00

120 Tablet/s

US$ 0.62

US$ 75.0025%US$ 100.00

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Product Description

Jakura 5mg medication is primarily used to treat autoimmune diseases. The 5 mg dosage is commonly prescribed for treating conditions like rheumatoid arthritis, psoriatic arthritis, ulcerative colitis, and ankylosing spondylitis. Sometimes, it is used off-label for conditions like alopecia areata or ankylosing spondylitis.

The medicine helps decrease pain and swelling in joints by reducing inflammation and tenderness; it slows down the progression of bone and joint damage. Jakura can be prescribed as a single medicine or in combination with other medicines, depending on a patient's health.

Working of the drug

Tofacitinib is the main active ingredient present in Jakura 5mg. It belongs to a class of drugs called Janus kinase (JAK) inhibitors. JAK enzymes play a role in the signaling pathways involved in the immune system, specifically in the production of inflammatory cytokines that contribute to the pathology of autoimmune diseases. By inhibiting JAK1, JAK2, JAK3, and sometimes TYK2 (depending on the formulation), tofacitinib reduces the inflammatory response and helps control symptoms of autoimmune conditions.

Precautions

Safety warning with Tofacitinib tablet

Jakura should not be used in patients who have a history of severe allergic reactions to tofacitinib. Inform your doctor if you have active serious infections (e.g., tuberculosis, opportunistic infections) or have a history of cancer, particularly lymphoproliferative disorders. Patients with liver disease are also recommended to inform a doctor about their health condition, medicines, and supplements they may be taking to avoid drug interactions. A doctor will closely monitor the signs of infection, liver function, blood counts, cholesterol levels, etc.

Tofacitinib may interact with other medications like immunosuppressants, CYP3A4 inhibitors or inducers, vaccines like ketoconazole, rifampin, etc.

Long-term use of JAK inhibitors has been associated with an increased risk of malignancies, particularly lymphoma and non-melanoma skin cancer. Also, careful monitoring is necessary, especially in patients with existing heart disease, due to the possible increased risk of heart-related issues.

Side Effects

Side effect of Tofacitinib tablet

The commonly reported side effects of the Tofacitinib tablet include increased risk of infections, headache, gastrointestinal issues, blood count changes, risk of blood clots, etc.

Some rare but serious side effects include serious infections such as tuberculosis, fungal and bacterial infections, cancer risk, and heart issues.

Contact your doctor if you are concerned about any side effects or if it becomes bothersome.

Jakura (tofacitinib) is an effective treatment for various autoimmune conditions, but it comes with a range of potential side effects, particularly related to immune suppression. Regular monitoring by a doctor is essential for the safe usage of this drug.

How to Use

Usage instructions for Tofacitinib tablet

The usual starting dose is 5 mg twice daily. Some patients may require a 10 mg twice-daily dose based on the severity of the condition and their response to treatment. The 5 mg dosage is often used for patients with milder symptoms or those more sensitive to the medication. Jakura is taken orally with or without food; it is best to take it at the same time each day to avoid missing the dose. Don’t stop taking the medicine abruptly; doing this can make your condition severe. It is best to speak to your doctor if you intend to stop this medicine for any reason.

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